To help you recall all that went down between them 10 years ago to lead to this plot twist, here's a timeline of Izzie and Karev's relationship on Grey's Anatomy.Īlex (Justin Chambers) and Izzie (Katherine Heigl) had an on-off relationship that was one of the staples of the first several seasons of Grey's. Even years later, the show of Karev leaving is still felt among the fandom, especially since Izzie was written off the show back in 2010, so it felt kind of out of left field. Izzie Stevens, and everyone basically lost it. Alex Karev left Grey Sloan Memorial Hospital to reunite with his ex, Dr. In Grey's Anatomy’s shocking March 5, 2019, episode, fans learned that Dr.
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